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What causes cardiac mitochondrial failure at high environmental temperatures?

J Exp Biol

October 2024

School of Biological Sciences, Thomas Building, University of Auckland, 3a Symonds St, Auckland 1010, New Zealand.

Article Synopsis
  • Mitochondria play a crucial role in producing ATP necessary for cellular function, particularly in crucial tissues like the heart and brain, and their dysfunction at high temperatures is linked to hyperthermic death.
  • As temperatures rise, the efficiency and capacity for ATP synthesis in cardiac and brain mitochondria decline, leading to insufficient ATP for cellular needs and potential organ failure.
  • This commentary explores potential causes of mitochondrial failure during hyperthermia, including increased leak respiration and structural changes in the inner mitochondrial membrane that could disrupt proton transport and reduce ATP production.
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