Thymus-derived natural Foxp3 CD4 regulatory T cells (nTregs) play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs) are critically involved in the maintenance and proliferation of nTregs. However, the mechanisms how DCs manage to keep the peripheral pool at constant levels remain poorly understood. Here, we describe that the NF-κB/Rel family transcription factor RelB controls the frequencies of steady-state migratory DCs (ssmDCs) in peripheral lymph nodes and their numbers control peripheral nTreg homeostasis. DC-specific RelB depletion was investigated in CD11c-Cre × RelB mice (RelB), which showed normal frequencies of resident DCs in lymph nodes and spleen while the subsets of CD103 Langerin dermal DCs (dDCs) and Langerhans cells but not CD103 Langerin dDC of the ssmDCs in skin-draining lymph nodes were increased. Enhanced frequencies and proliferation rates were also observed for nTregs and a small population of CD4 CD44 CD25 memory-like T cells (Tml). Interestingly, only the Tml but not DCs showed an increase in IL-2-producing capacity in lymph nodes of RelB mice. Blocking of IL-2 reduced the frequency of nTregs but increased the Tml frequencies, followed by a recovery of nTregs. Taken together, by employing RelB mice with increased frequencies of ssmDCs our data indicate a critical role for specific ssmDC subsets for the peripheral nTreg and IL-2 Tml frequencies during homeostasis.
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http://dx.doi.org/10.3389/fimmu.2017.00726 | DOI Listing |
Nat Commun
December 2024
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
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View Article and Find Full Text PDFNat Commun
December 2024
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
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View Article and Find Full Text PDFEur Heart J Case Rep
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Department of Cardiology, Klinik Floridsdorf, Brünnerstraße 68, Vienna 1210, Austria.
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