N-Heterocyclic Carbene and Chiral Brønsted Acid Cooperative Catalysis for a Highly Enantioselective [4+2] Annulation.

Synthesis (Stuttg)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Published: January 2017

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A chiral NHC/Brønsted acid cooperative catalysis system has been developed for asymmetric annulation of functionalized benzaldehydes and activated ketones through dearomative generation of dienolate.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496987PMC
http://dx.doi.org/10.1055/s-0036-1588349DOI Listing

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