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Association Between Serum Antinuclear Antibody and Polycystic Ovarian Syndrome in Reproductive Women Aged 18 to 35 Years: A Quest for an Autoimmune Marker.
Cureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences, Raipur, IND.
Introduction: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrinal physiological disorder characterized by chronic oligo-ovulation or an-ovulation, hyperandrogenism, and polycystic morphology in ovaries on transvaginal or abdominal ultrasound. Hyperandrogenism and insulin resistance are already well-documented pathophysiological mechanisms in PCOS. Besides this, autoimmunity has been hypothesized in its pathogenesis.
View Article and Find Full Text PDFDeveloping and assessing the "MultiLife" intervention: a mobile health-based lifestyle toolkit for cardiometabolic multimorbidity in diabetes and hypertension management - a type 1 hybrid effectiveness-implementation trial protocol.
BMC Public Health
January 2025
Indian Council of Medical Research, New Delhi, India.
Background: Cardiometabolic multimorbidity (CMM), characterized by the coexistence of diabetes, hypertension, and cardiovascular disease, poses a major health challenge in India, particularly in rural areas with limited healthcare resources. Lifestyle interventions can manage cardiometabolic risk factors, yet adherence remains suboptimal. Mobile health (mHealth) interventions offer a scalable approach for managing CMM by promoting behaviour change and medication adherence.
View Article and Find Full Text PDFMusculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury-a randomized, double-blind, and placebo-controlled pilot study.
Front Neurol
December 2024
Brain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, United States.
Article Synopsis
- High-dose testosterone replacement therapy (TRT) combined with finasteride offers benefits such as improved body composition, muscle strength, and bone density in older men, while mitigating the risk of prostate enlargement.
- A pilot study involved 12 men with spinal cord injuries, demonstrating that TRT with finasteride significantly increased lean body mass and muscle size, alongside enhancing bone mineral density compared to a placebo.
- Results suggest TRT + finasteride reduced fat mass and improved muscular strength, with measurable benefits observed as early as 6 months into the treatment, indicating its potential effectiveness for men with low testosterone post-injury.
Maternal investment, body condition and calf growth in humpback whales.
J Physiol
January 2025
Marine Mammal Research Program, Hawai'i Institute of Marine Biology, University of Hawai'i at Mānoa, Kāne'ohe, Hawai'i, USA.
Given recent declines in North Pacific humpback whale (Megaptera novaeangliae) reproductive output and calf survival, there is additional urgency to better understand how mother-calf pairs allocate energy resources across their migratory cycle. Here, unoccupied aerial system (UAS; or drone) photogrammetry was used to quantify the body size and condition (BC) of humpback whales on their Hawai'i (HI) breeding and Southeast Alaska (SEAK) feeding grounds. Between 2018 and 2022, we collected 2410 measurements of 1659 individuals.
View Article and Find Full Text PDFEnergetic cost of gestation and prenatal growth in humpback whales.
J Physiol
January 2025
Marine Mammal Research Program, Hawai'i Institute of Marine Biology, University of Hawai'i at Mānoa, Kāne'ohe, HI, USA.
Improving our understanding of energy allocation in reproduction is key for accurately parameterizing bioenergetic models to assess population responses to environmental perturbations and anthropogenic disturbance. We quantified the energetic cost of gestation in humpback whales (Megaptera novaeangliae) using historical whaling records, non-invasive unoccupied aerial system (UAS) photogrammetry and post mortem tissue samples. First, we estimated relative birth size using body length measurements of 678 mother-fetus pairs from historical whaling records and 987 mother-calf pairs measured in situ using UAS-photogrammetry.
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