AI Article Synopsis
- * The study compared apo E genotyping and lipoprotein electrophoresis by analyzing data from a lipid clinic over three years, involving 62 patients.
- * Results showed that only 3 out of 16 patients with a broad beta band on electrophoresis had the E2E2 genotype, indicating poor agreement between the two diagnostic methods due to potential misinterpretation of electrophoresis results.
Article Abstract
Dysbetalipoproteinemia is often associated with apolipoprotein E2E2 homozygosity; however, lipoprotein electrophoresis may also be used to assist in the diagnosis. The aim of this study was to compare apolipoprotein E (apo E) genotyping and lipoprotein electrophoresis in investigating dysbetalipoproteinemia. Data were collected over a three-year period from a lipid clinic in a tertiary referral centre and reviewed for apo E genotyping and lipoprotein electrophoresis. Sixty-two patients had both apo E genotyping and lipoprotein electrophoresis. Of these, 16 patients showed broad beta band on electrophoresis. However, only 3 of them had apo E2E2 homozygosity on genotyping. Lipoprotein electrophoresis and apo E genotyping results showed poor concordance. This was primarily due to visual interpretation error of lipoprotein electrophoresis which may over diagnose dysbetalipoproteinemia.
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