Ethnopharmacological Relevance: Antrodia camphorata (AC) is a well known traditional Chinese medicinal mushroom in Taiwan, has been used to treat various diseases including cancer.
Materials And Methods: In this study, we investigated the anti-metastatic and anti-EMT properties of a fermented culture broth of AC in human colon SW480 and metastatic SW620 cancer cells in vitro.
Results: AC down-regulates claudin-1 and inhibits the proliferation and colony-formation abilities of both SW620 and SW480 cells. In highly metastatic SW620 cells, non-cytotoxic concentrations of AC significantly inhibited migration/invasion, accompanied by the down-regulation of MMP-2 and MMP-9 proteins. AC decreased nuclear translocation of Wnt/β-catenin through a GSK3β-dependent pathway. AC consistently inhibited EMT by up-regulating the epithelial and downregulating the mesenchymal marker proteins. In SW480 cells, AC suppressed migration/invasion potentially through the inhibition of the PI3K/AKT/NFκB signaling pathways without altering the expression levels of β-catenin and GSK3β proteins.
Conclusion: Altogether, this study demonstrates the anti-metastatic and anti-EMT activities of AC, which may contribute to the development of a chemopreventive agent for colon cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2017.07.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dietary Polysaccharide Intervention Modulates Clinical Symptoms by Regulating Ovarian Metabolites and Restructuring the Intestinal Microbiota in Rats with Letrozole-Induced PCOS.
J Agric Food Chem
December 2024
Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi 541100, China.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder. This study investigated the mitigating effects of the polysaccharide (ACP) on a letrozole-induced PCOS rat model. Results demonstrated that ACP reduced obesity and ameliorated dyslipidemia in PCOS rats.
View Article and Find Full Text PDFUnlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Universidad Espíritu Santo, Samborondón, Ecuador.
Article Synopsis
- * Recent studies highlight its pharmacological properties, particularly those of methyl antcinate A (MAA), which shows significant anti-cancer, anti-inflammatory, and gastro-protective effects.
- * There is a need for further research and clinical trials to better understand MAA's anti-tumor effects and to explore the structure-activity relationships of antcins for potential therapeutic applications.
Protective Effects of Antcin H Isolated from Antrodia cinnamomea Against Neuroinflammation in Huntington's Disease via NLRP3 Inflammasome Inhibition.
J Neuroimmune Pharmacol
December 2024
Institute of Molecular Biology, National Chung Hsing University, No. 145 Xingda Rd., South Dist., Taichung, 402202, Taiwan.
Article Synopsis
- - Huntington's disease (HD) is a genetic neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene, leading to the accumulation of harmful mutant proteins in nerve cells.
- - The NLRP3 inflammasome plays a crucial role in inflammation and its overactivation contributes to neurodegeneration in HD; inhibiting it showed potential benefits in mice by reducing toxic inflammation and neuronal damage.
- - Antcin-H, a compound derived from the medicinal fungus Antrodia cinnamomea, was found to decrease neuroinflammation and toxicity while improving motor function and survival rates in a mouse model of HD, indicating its potential as a therapeutic option.
[Not Available].
Angew Chem Int Ed Engl
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Article Synopsis
- Researchers identified three important enzymes (AcCYP4, AcSDR6, AcSMT1) that play a role in the biosynthesis of lanostane-type triterpenoids in Antrodia camphorata.
- The catalytic mechanisms of AcSDR6 were analyzed using crystal structure analysis to understand how it works.
- These enzymes can potentially be used to synthesize at least 11 major types of Antrodia lanostanoids.
Antrodia cinnamomea triterpenoids attenuate cardiac hypertrophy via the SNW1/RXR/ALDH2 axis.
Redox Biol
December 2024
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, 100191, China; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University, Beijing, 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. Electronic address:
Aldehyde dehydrogenase 2 (ALDH2), a pivotal enzyme in the metabolism of toxic aldehydes produced by oxidative stress, has been demonstrated to play a cardioprotective role in cardiovascular diseases. Antrodia cinnamomea triterpenoids (ACT) is a medicinal mushroom with anti-inflammatory and antioxidant properties, and our previous study found that ACT can exert anti-fatty liver effects by regulating ALDH2. This study aimed to elucidate the impact of ACT and its monomer on cardiac hypertrophy and investigate the relationship between its pharmacological mechanism and ALDH2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!