The phase changes of biochemical characteristics of hypothalamic mediator systems have been demonstrated in C57Bl mice with Lewis carcinoma. Phase I generated due to implantation of tumour cells was characterized by predominant exciting processes, which can increase the dissemination and sedimentation of tumour cells. During phases II--a period of metastatic formation--the normalization was found in hypothalamic mediator systems, which along with the activation of serotoninergic mechanisms promotes the inhibition of antitumour resistance. Phase III was related to the acute activation of mediator exciting processes and weakening of inhibition processes. Stress reactions arising under these conditions can stimulate tumour cell extravasation and development, and active growth of early metastatic nodules. The depletion of exciting mediator systems of the hypothalamus followed by general exhaustion of the organism was observed in phase IV.
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