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| http://dx.doi.org/10.1007/s00213-017-4674-x | DOI Listing |
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Impaired cognitive flexibility following NMDAR-GluN2B deletion is associated with altered orbitofrontal-striatal function.
Neuroscience
November 2021
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA; New Mexico Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM, USA. Electronic address:
A common feature across neuropsychiatric disorders is inability to discontinue an action or thought once it has become detrimental. Reversal learning, a hallmark of executive control, requires plasticity within cortical, striatal and limbic circuits and is highly sensitive to disruption of N-methyl-d-aspartate receptor (NMDAR) function. In particular, selective deletion or antagonism of GluN2B containing NMDARs in cortical regions including the orbitofrontal cortex (OFC), promotes maladaptive perseveration.
View Article and Find Full Text PDFAlcohol exposure in utero disrupts cortico-striatal coordination required for behavioral flexibility.
Neuropharmacology
May 2021
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA; New Mexico Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM, USA. Electronic address:
Deficits in behavioral flexibility are a hallmark of multiple psychiatric, neurological, and substance use disorders. These deficits are often marked by decreased function of the prefrontal cortex (PFC); however, the genesis of such executive deficits remains understudied. Here we report how the most preventable cause of developmental disability, in utero exposure to alcohol, alters cortico-striatal circuit activity leading to impairments in behavioral flexibility in adulthood.
View Article and Find Full Text PDFErratum to: Perseveration in a spatial-discrimination serial reversal learning task is differentially affected by MAO-A and MAO-B inhibition and associated with reduced anxiety and peripheral serotonin levels.
Psychopharmacology (Berl)
August 2017
Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK.
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