Here we show how it is possible to make estimates of brain structure based on MEG data. We do this by reconstructing functional estimates onto distorted cortical manifolds parameterised in terms of their spherical harmonics. We demonstrate that both empirical and simulated MEG data give rise to consistent and plausible anatomical estimates. Importantly, the estimation of structure from MEG data can be quantified in terms of millimetres from the true brain structure. We show, for simulated data, that the functional assumptions which are closer to the functional ground-truth give rise to anatomical estimates that are closer to the true anatomy.
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http://dx.doi.org/10.1016/j.neuroimage.2017.06.049 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130.
Task-free brain activity affords unique insight into the functional structure of brain network dynamics and has been used to identify neural markers of individual differences. In this work, we present an algorithmic optimization framework that directly inverts and parameterizes brain-wide dynamical-systems models involving hundreds of interacting neural populations, from single-subject M/EEG time-series recordings. This technique provides a powerful neurocomputational tool for interrogating mechanisms underlying individual brain dynamics ("precision brain models") and making quantitative predictions.
View Article and Find Full Text PDFPLoS Biol
January 2025
Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, United States of America.
Perceptual awareness results from an intricate interaction between external sensory input and the brain's spontaneous activity. Pre-stimulus ongoing activity influencing conscious perception includes both brain oscillations in the alpha (7 to 14 Hz) and beta (14 to 30 Hz) frequency ranges and aperiodic activity in the slow cortical potential (SCP, <5 Hz) range. However, whether brain oscillations and SCPs independently influence conscious perception or do so through shared mechanisms remains unknown.
View Article and Find Full Text PDFNeuroimage
January 2025
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA. Electronic address:
Noninvasive brain stimulation of the primary motor cortex has been shown to alter therapeutic outcomes in stroke and other neurological conditions, but the precise mechanisms remain poorly understood. Determining the impact of such neurostimulation on the neural processing supporting motor control is a critical step toward further harnessing its therapeutic potential in multiple neurological conditions affecting the motor system. Herein, we leverage the excellent spatio-temporal precision of magnetoencephalographic (MEG) imaging to identify the spectral, spatial, and temporal effects of high-definition transcranial direct current stimulation (HD-tDCS) on the neural responses supporting motor control.
View Article and Find Full Text PDFJ Neurosci
January 2025
Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo FI-00076, Finland.
Our visual system enables us to effortlessly navigate and recognize real-world visual environments. Functional magnetic resonance imaging (fMRI) studies suggest a network of scene-responsive cortical visual areas, but much less is known about the temporal order in which different scene properties are analysed by the human visual system. In this study, we selected a set of 36 full-colour natural scenes that varied in spatial structure and semantic content that our male and female human participants viewed both in 2D and 3D while we recorded magnetoencephalography (MEG) data.
View Article and Find Full Text PDFJ Physiol
January 2025
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Motor cortical high-gamma oscillations (60-90 Hz) occur at movement onset and are spatially focused over the contralateral primary motor cortex. Although high-gamma oscillations are widely recognized for their significance in human motor control, their precise function on a cortical level remains elusive. Importantly, their relevance in human stroke pathophysiology is unknown.
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