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Engineering Saccharomyces cerevisiae for medical applications.
Microb Cell Fact
January 2025
Chair of Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition and Health, University of Bayreuth, 95326, Kulmbach, Germany.
Background: During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable. Following the trend, the genetic engineering of the baker's yeast, Saccharomyces cerevisiae, propelled its status from an instrumental ally in the food industry to a therapy and prophylaxis aid.
Main Text: In this review, we scrutinize the main applications of engineered S.
Accurate predictions on small data with a tabular foundation model.
Nature
January 2025
Machine Learning Lab, University of Freiburg, Freiburg, Germany.
Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science. The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is essential for various applications as diverse as biomedical risk models, drug discovery and materials science. Although deep learning has revolutionized learning from raw data and led to numerous high-profile success stories, gradient-boosted decision trees have dominated tabular data for the past 20 years.
View Article and Find Full Text PDFMental Health Care Works: Insights From a Public Service Campaign.
Focus (Am Psychiatr Publ)
January 2025
American Psychiatric Association Foundation, Washington, DC (Hodzic, Andrews); Department of Psychiatry, Massachusetts General Hospital, McLean Hospital, Harvard Medical School, Boston, Massachusetts (Butler).
The United States is experiencing a mental health crisis, with COVID-19 increasing the prevalence of mental health concerns and demand for services, but also leaving millions without care, including many who do not know that treatment is needed or available. The American Psychiatric Association Foundation's Mental Health Care Works campaign was informed by results from an assessment of mental health awareness and perceptions of adults in the United States. These results highlighted the need for more public education about the efficacy of mental health care and ongoing need to normalize treatment and make care more accessible and relatable.
View Article and Find Full Text PDFLeft ventricular assist devices (LVADs) have been used as a bridge to transplantation in patients with advanced heart failure. In this case, LVAD therapy was used as a destination therapy for 16 years, representing the longest documented and continuously ongoing support with the original implanted device.
View Article and Find Full Text PDFDr. George Papanicolaou: Inventor of the Pap Smear and Father of Modern Cytology.
Cureus
December 2024
Research, Orlando College of Osteopathic Medicine, Winter Garden, USA.
The Pap smear is widely recognized in medicine as the single most successful contributor to cancer screening and preventative care. Women have Dr. George Papanicolaou (1870-1962) to thank for this groundbreaking contribution to their healthcare-a discovery that, fascinatingly, was made incidentally during his study of ovulation cycles in guinea pigs.
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