C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

Mol Biosyst

Department of Chemistry, Michigan State University, 578 S. Shaw Ln, East Lansing, MI 48824, USA. and Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Drive, East Lansing, MI 48824-6962, USA.

Published: July 2017

Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, after nearly 30 years of positive research results, C-peptide is still not being co-administered with insulin to diabetic patients. The following review discusses the potential of C-peptide as an auxilliary replacement therapy and why it's not currently being used as a therapeutic.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796410PMC
http://dx.doi.org/10.1039/c7mb00199aDOI Listing

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