AI Article Synopsis
- A new series of -butyl 2-(substituted benzamido) phenylcarbamates was synthesized using -butyl 2-amino phenylcarbamate and various substituted carboxylic acids, resulting in high yields.
- The synthesized compounds were tested for anti-inflammatory activity in rats, showing effectiveness comparable to the standard drug indomethacin, with inhibition rates between 39.021% and 54.239%.
- In silico docking studies were conducted to support the experimental findings and provide further insights into the compounds' potential as anti-inflammatory agents.
Article Abstract
A series of new -butyl 2-(substituted benzamido) phenylcarbamate - were synthesized by the condensation of -butyl 2-amino phenylcarbamate () with various substituted carboxylic acid in the presence of EDCI and HOBt as coupling reagent, obtain in excellent yields. The structures of all newly synthesized compounds were characterized spectroscopically and evaluated for in vivo anti-inflammatory activity compared to the standard drug, indomethacin, by using the carrageenan-induced rat paw edema protocol. Most of the compounds exhibited a promising anti-inflammatory activity within 9 to 12 h, the percentage of inhibition values ranging from 54.239 to 39.021%. The results revealed that the compounds and exhibited better or equivalent anti-inflammatory activity with the percentage of inhibition of 54.239 and 54.130%, respectively, which was comparable to standard drug. In addition to experimental results, in silico docking studies was used as a tool to verify and expand the experimental outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480262 | PMC |
| http://dx.doi.org/10.1007/s12154-017-0168-x | DOI Listing |
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