Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500573 | PMC |
http://dx.doi.org/10.1038/s41598-017-04956-3 | DOI Listing |
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