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Article Synopsis
  • - Calciphylaxis is a serious condition characterized by the calcification of small blood vessels, leading to tissue damage and ulcers, often seen in individuals with end-stage renal disease but can also affect those without kidney issues.
  • - Risk factors for calciphylaxis include diabetes, hyperparathyroidism, certain cancers, use of warfarin, liver disease, and autoimmune disorders, making it essential to recognize these factors for effective diagnosis and treatment.
  • - A case study describes a 58-year-old man with end-stage renal disease who developed penile calciphylaxis, leading to rapid tissue necrosis; he chose conservative treatment over surgery, opting for local wound care and antibiotics instead.
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Calciphylaxis in a 30-Year-Old Woman With Alcoholic Cirrhosis: A Case Report.

Cureus

September 2024

Department of Radiology and Nuclear Medicine, Jackson Memorial Hospital, Miami, USA.

Article Synopsis
  • Calciphylaxis is a rare but serious condition affecting patients with end-stage renal disease (ESRD), leading to poor outcomes due to calcium and phosphorus buildup in blood vessels and soft tissues.
  • Diagnosis can be made through skin biopsies or imaging techniques like X-ray and bone scintigraphy, emphasizing the significance of these methods.
  • This report discusses a case of a 30-year-old woman with calciphylaxis, pointing out the effectiveness of bone scintigraphy for diagnosis and the crucial role of organ transplant for adequate treatment.
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Calciphylaxis (CP) is a serious, potentially life-threatening disease that presents with medial calcification of small-sized vessels and painful ischemic ulcerations. Although calciphylaxis is frequently seen in patients with end-stage kidney disease on dialysis (calcific uremic arteriolopathy, CUA), there are reported cases of nonuremic calciphylaxis (NUC), which often remain undiagnosed. We conducted a retrospective chart review at our dermatological hospital and evaluated data concerning the epidemiology, comorbidities, medication, laboratory abnormalities, and therapeutic approaches of 60 patients diagnosed with calciphylaxis between 01/2012 and 12/2022.

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Article Synopsis
  • This text discusses two rare cases of calciphylaxis that showed eye-related issues without typical skin symptoms, aiming to increase awareness of the condition.
  • The cases include a 76-year-old woman with kidney failure and anterior ischemic optic neuropathy (AION), and a 44-year-old man on dialysis with AION and central retinal artery occlusion (CRAO).
  • It emphasizes the importance of recognizing calciphylaxis in kidney patients with eye problems, and suggests a temporal artery biopsy for accurate diagnosis to prevent unnecessary treatments like steroids.
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