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Circles of Life: linking metabolic and epigenetic cycles to immunity.
Immunology
November 2020
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications.
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