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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. | LitMetric
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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA.

Mostafa Kamal Masud Md Nazmul Islam Md Hakimul Haque Shunsuke Tanaka Vinod Gopalan Gursel Alici Nam-Trung Nguyen Alfred K Lam Md Shahriar A Hossain Yusuke Yamauchi Muhammad J A Shiddiky

Chem Commun (Camb)

Australian Institute for Innovative Materials (AIIM), University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia.

Published: July 2017

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFeONC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

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 Source
http://dx.doi.org/10.1039/c7cc04789dDOI Listing

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