Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death.

Mol Biosyst

School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan.

Published: August 2017

AI Article Synopsis

  • Hydrogen sulfide (HS) is a vital signaling molecule that helps protect heart cells (cardiomyocytes) from damage due to lack of oxygen (ischemia).
  • Researchers developed a tiny micelle that delivers HS directly inside cells, showing promising results in preventing cell death (apoptosis) during simulated ischemia.
  • The study highlights the potential of HS as a therapeutic strategy for enhancing heart cell survival in low-oxygen conditions.

Article Abstract

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized HS donor micelle releases HS intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

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Source
http://dx.doi.org/10.1039/c7mb00191fDOI Listing

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