Numerical instability is an important issue that should be addressed in the time-domain equivalent source method (TESM). This study proposes a multistep method to stabilize TESM when using the measured acoustic pressure data to optimize equivalent source strengths. Unlike the conventional single-step method that solves each time step in the time-marching process of TESM, the proposed method performs a one-time solution for several time steps. The multistep solution can potentially reduce the accumulation rate of error, and improves filtering effects by changing the structure of the matrix that needs to be inverted when the truncated singular value decomposition or Tikhonov regularization is used in the time-marching process. Numerical simulations with three examples demonstrate the effectiveness of the multistep method in improving the stability of solutions compared with the single-step method. Effects of the number of merged time steps on the solutions are also discussed to guide the selection process. Finally, the sensitivity of the multistep method to numerical parameters is investigated to demonstrate its consistency under different configurations of numerical parameters.
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http://dx.doi.org/10.1121/1.4988945 | DOI Listing |
Food Sci Nutr
January 2025
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia University of Belgrade Belgrade Serbia.
(L.) Roxb. and (L.
View Article and Find Full Text PDFToxicon
January 2025
Applied Immunology and Morphology Research Centre, NuPMIA, Morphology Area, Faculty of Medicine, University of Brasília, UnB, Brasília, Distrito Federal, Brazil. Electronic address:
Amphibian skin is a rich source of molecules with biotechnological potential, including the tryptophyllin family of peptides. Here, we report the identification and characterization of two tryptophyllin peptides, FPPEWISR and FPWLLS-NH, from the skin of the Central Dwarf Frog, Physalaemus centralis. These peptides were identified through cDNA cloning and sequence comparison.
View Article and Find Full Text PDFRes Social Adm Pharm
January 2025
Division of Social and Administrative Sciences & Sonderegger Research Center for Improved Medication Outcomes, University of Wisconsin-Madison School of Pharmacy, 777 Highland Avenue, Madison, WI, 53705, USA. Electronic address:
Introduction: Misuse of over-the-counter (OTC) medications by older adults (age 65+) can comprise Drug-Age, Drug-Drug, Drug-Disease, and Drug-Label types. Pharmacies in the United States are prevalent sources of OTCs and are an apt setting to address OTC misuse. Senior Safe™ is a pharmacy-system redesign for preventing older adult OTC misuse.
View Article and Find Full Text PDFPLoS Comput Biol
January 2025
Department of Computer Science, Colorado State University, Fort Collins, Colorado, United States of America.
Complex deep learning models trained on very large datasets have become key enabling tools for current research in natural language processing and computer vision. By providing pre-trained models that can be fine-tuned for specific applications, they enable researchers to create accurate models with minimal effort and computational resources. Large scale genomics deep learning models come in two flavors: the first are large language models of DNA sequences trained in a self-supervised fashion, similar to the corresponding natural language models; the second are supervised learning models that leverage large scale genomics datasets from ENCODE and other sources.
View Article and Find Full Text PDFAm J Sports Med
January 2025
Service de chirurgie orthopédique et traumatologique, CHU de Toulouse, France.
Background: The surgical management of bursal-sided partial-thickness rotator cuff tendon tears is controversial. The 2 methods used are in situ repair (ISR), preserving the contingent of intact articular tendon fiber, or tear completion before repair (TCBR) according to the operating surgeon's usual technique. No study with sufficient power has demonstrated a superior technique.
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