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Microsensor systems for cell metabolism - from 2D culture to organ-on-chip (2019-2024).
Lab Chip
January 2025
Laboratory for Electrical Instrumentation and Embedded Systems, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany.
Cell cultures, organs-on-chip and microphysiological systems become increasingly relevant as models, , in drug development, disease modelling, toxicology or cancer research. It has been underlined repeatedly that culture conditions and metabolic cues have a strong or even essential influence on the reproducibility and validity of such experiments but are often not appropriately measured or controlled. Here we review microsensor systems for cell metabolism for the continuous measurement of culture conditions in microfluidic and lab-on-chip platforms.
View Article and Find Full Text PDFStandardization of myocardial protection: comment on "Cardiac surgery 2023 reviewed".
Thorac Cardiovasc Surg
December 2024
Cardiovascular Departement, University Hospital Bern, Bern, Switzerland.
There have been few recent innovations since the introduction of cardioplegia more than 50 years ago. Surprisingly, cardioplegia as one of the most essential steps in terms of heart muscle protection during a surgical procedure requiring cardiac arrest has never been really standardized. As a consequence, a considerable variety of cardioplegic solutions and applications have developed: cold versus warm, crystalloid versus blood cardioplegia, antegrade versus retrograde or both, as well as different time schedules for repeated administration.
View Article and Find Full Text PDFCarbon ion radiation therapy in prostate cancer: The importance of dosage.
World J Radiol
November 2024
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States.
In this article, we comment on the article by Ono . We focus specifically on the carbon ion radiotherapy studies and the method to calculate the dosing schedule. While photon hypofractionated radiotherapy in prostate cancer has demonstrated improvement in tumor control with reduced gastrointestinal toxicity compared to conventional radiotherapy, carbon ion radiotherapy (CIRT) offers additional physical and biological advantages.
View Article and Find Full Text PDFIs 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?
World J Hepatol
November 2024
Hepatosplenic Surgery Center, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Article Synopsis
- The article discusses the challenges of treating intrahepatic cholangiocarcinoma (iCCA), as most patients do not respond well to existing therapies and highlights ongoing efforts to find new molecular targets.
- It focuses on a study by Tang which examines the role of the PSMD6 gene in iCCA cells, finding it crucial for cell proliferation and overexpressed in iCCA tissues, although the study has limitations regarding its methods and insights into mechanisms.
- The editorial also mentions recent advancements in targeted drug therapies and immunotherapies for iCCA, and underscores the potential of CRISPR technology and other computational methods in cancer research.
Unlocking the Potential of Submental Intubation - Redefining Airway Management in Craniomaxillofacial Trauma Patients.
Craniomaxillofac Trauma Reconstr
August 2024
Department of Oral and Maxillofacial Surgery,, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth Deemed to be University, Gujarat, India.
Study Design: Submental intubation is and underutilized alternative to traditional techniques of intubation. Complications associated can indeed deter surgeons and anesthesiologist from performing it. Surgeons may opt for submental intubation if they believe that its advantages outweigh the potential risks of the procedure.
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