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Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway.
Cell Oncol (Dordr)
January 2025
Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Background: Gastric cancer (GC) ranks as the fourth leading cause of cancer-related deaths worldwide, with most patients diagnosed at advanced stages due to the absence of reliable early detection biomarkers.
Methods: RNA-sequencing was conducted to identify the differentially expressed genes between GC tissues and adjacent normal tissues. CCK8, EdU, colony formation, transwell, flow cytometry and xenograft assays were adopted to explore the biological function of ZBTB10 and betulinic acid (BA) in GC progression.
Evaluating leadership development programs in healthcare organizations: A profile from practice.
Health Serv Manage Res
February 2025
LSU Shreveport, Shreveport, LA, USA.
To enhance leadership acumen and intelligence among the managerial ranks, many healthcare organizations establish leadership development programs. Doing so makes perfect sense as the caliber of leadership within health and medical institutions profoundly influences all aspects of operation. Although leadership development programs are very capable mechanisms for advancing the state of leadership within healthcare organizations, a notable enhancement-evaluation-is needed to maximize their potential.
View Article and Find Full Text PDFPeriodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.
J Dent Sci
January 2025
Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Background/purpose: Peroxisome proliferator-activated receptor γ (PPARγ) is a major transcription factor of energy metabolism-associated genes, and three PPARγ isoforms have been identified in periodontal tissues and cells. When energy metabolism homeostasis is affected by PPARγ downregulation in periodontal ligament fibroblasts (PDLFs), osteo/cementogenic abilities are markedly lost. Herein, we investigated whether PPARγ agonists promote periodontal tissue regeneration, and which PPARγ isoforms and metabolic pathways are indispensable for osteo/cementogenic abilities.
View Article and Find Full Text PDFEffect of nalbuphine on analgesia and pain factors after gastric cancer resection.
World J Gastrointest Surg
January 2025
Department of Anesthesiology, Suzhou Ninth People's Hospital, Suzhou 215299, Jiangsu Province, China.
Background: Gastric cancer (GC) is a prevalent tumor in the digestive system, with around one million new cases reported annually, ranking it as the third most common malignancy. Reducing pain is a key research focus. This study evaluates the effect of nalbuphine on the analgesic effect and the expression of pain factors in patients after radical resection.
View Article and Find Full Text PDFHow does residency program reputation influence American shoulder and elbow surgeons fellowship match results?
JSES Rev Rep Tech
February 2025
Department of Orthopaedic Surgery, Henry Ford Hospital, Henry Ford Health, Detroit, MI, USA.
Background: Postresidency training is becoming increasingly common among orthopedic surgeons, with shoulder and elbow surgery growing as a desired subspeciality. There is limited data evaluating how the reputation of an applicants' orthopedic residency influences the outcome of the shoulder and elbow fellowship match. The purpose of this study was to determine if applicants from residencies with better reputation have more favorable odds during the match process compared to applicants from residencies with a less prestigious reputation.
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