We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498056 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180347 | PLOS |
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