Multiseptate gallbladder is a congenital abnormality categorized as a gallbladder shape variant with some 20 cases reported thus far in the literature. Clinical presentation may be highly variable, ranging from asymptomatic to chronic pain in the right upper quadrant, cholecystitis, and even pancreatitis. It may be associated with other bile duct abnormalities such as choledochal cyst, ectopic gallbladder or anomalous biliopancreatic junction.

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Introduction: Multiseptate gallbladder (MSG) is an uncommon congenital condition characterized by internal septa dividing the gallbladder into multiple compartments. This condition poses unique challenges in diagnosis and management due to its rarity and varied clinical presentations.

Case Presentation: A 4-year-old female presented with a three-month history of colicky abdominal pain.

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Multiseptated gallbladder also known as "Honeycomb gallbladder" is a rare condition that was first described by Tandon in 1963. It is described as a congenital anomaly in most of the cases. It may be asymptomatic or may lead symptoms.

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A very uncommon congenital defect called multi-septate gallbladder (MSG) typically results from wrinkling of the gallbladder membrane or insufficient vacuole formation of the growing bud of the gallbladder. The many septa giving MSG its honeycomb appearance cover the whole lumen of the gallbladder. MSG, hyperplastic cholecystitis, and cholecystitis are a few causes of this ultrasonography finding.

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Multiseptate gallbladder presenting with biliary colic.

J Surg Case Rep

September 2022

Department of Internal Medicine, OhioHealth Riverside Methodist Hospital, Columbus, OH, USA.

Common diagnoses associated with right upper quadrant and epigastric pain include cholecystitis, peptic ulcer disease (PUD), biliary colic, gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS). Multiseptate gallbladder is a rare congenital anomaly that can cause symptoms of biliary colic, however it may present with atypical symptoms, which can prolong definitive diagnosis and treatment. We present a case of multiseptate gallbladder in a 21-year-old female who initially presented with GERD and IBS.

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