AI Article Synopsis
- Disseminated cutaneous histoplasmosis (DCH) occurs in HIV-positive patients and the link between immune status (measured by CD4 counts) and the infection is not well understood.
- This study involved seven HAART-treated HIV-positive patients with DCH, examining their clinical symptoms and CD4 counts before biopsy from January 2004 to December 2014.
- Findings indicated that while CD4 counts did not correlate with lesion appearance, lower counts were linked to yeast-like cells in the skin, and higher counts allowed for granuloma formation.
Article Abstract
Background: Disseminated cutaneous histoplasmosis (DCH) is one of the manifestations of systemic histoplasmosis infection in HIV-positive patients. Interaction between host immune status and histoplasmosis infection is still poorly understood. It is thought that immune status, represented by CD4 counts, may be correlated with clinical and histopathological findings.
Objective: To correlate the CD4 counts with the different clinical and histopathological findings in cutaneous histoplasmosis.
Methods: This was a serial case report of seven HAART-treated HIV positive patients with disseminated histoplasmosis observed within the period of January 2004 through December 2014 from the Dermatology and Venereology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. The patients came with different complaints and clinical findings. CD4 counts were recorded prior to lesion biopsy.
Results: The CD4 counts were independent from clinical morphology and distribution of lesions. Lower CD4 counts were associated with the presence of intraepidermal yeast-like cells, whereas there is the ability of forming granulomas at higher CD4 counts.
Conclusion: CD4 count correlates to histopathological findings of cutaneous histoplasmosis.
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| http://dx.doi.org/10.1111/ijd.13679 | DOI Listing |
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