AI Article Synopsis

  • Infants with KMT2A (MLL)-rearranged acute lymphoblastic leukemia (MLL-r ALL) have poor outcomes even with aggressive treatments, like stem cell transplants.
  • Epigenetic changes are believed to play a major role in the development of this type of leukemia, leading researchers to explore epigenetic drugs as potential therapies.
  • A specific case showed that after a relapse post-transplant, the infant achieved and maintained remission for 10 months with azacitidine, before successfully undergoing a second stem cell transplant.

Article Abstract

The outcome for infants with KMT2A (MLL)-rearranged acute lymphoblastic leukemia (MLL-r ALL) is dismal despite intensive therapy, including hematopoietic stem cell transplantation (HSCT). Epigenetic dysregulation is considered a key driver of MLL-r leukemogenesis, which theoretically supports the use of epigenetic modifiers as a treatment option. We report an infant MLL-r ALL case with post-HSCT relapse. After achieving a second remission, which was maintained for 10 months using only the DNA methyltransferase inhibitor, azacitidine, the patient successfully received the second HSCT. This report describes the clinical effectiveness of azacitidine for the treatment of infant MLL-r ALL.

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Source
http://dx.doi.org/10.1002/pbc.26697DOI Listing

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