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Re-Evaluating the Use of Glyphosate-based Herbicides: Implications on Fertility.
Reprod Sci
March 2025
Departments of Obstetrics and Gynecology and Biochemistry and Molecular Biology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Glyphosate-based herbicides (GBHs) are the most widely used herbicides in the United States, accounting for 19% of estimated global use. Although the Environmental Protection Agency (EPA) has reaffirmed that the active ingredient glyphosate (GLY) is safe for humans, recent studies on exposure have suggested association with cancer, metabolic disorders, endocrine disruption and infertility, Alzheimer's and Parkinson's disease, and psychological disorders. Current literature on the effects of GLY exposure on reproductive function suggests potential clinical implications on women's reproductive health, including polycystic ovarian syndrome (PCOS), endometriosis, infertility, and adverse pregnancy outcomes.
View Article and Find Full Text PDFDemystifying Meckel's diverticulum - a guide for the gastroenterologist.
Curr Opin Gastroenterol
March 2025
Academic Unit of Gastroenterology, Royal Hallamshire Hospital.
Purpose Of Review: Meckel's diverticulum (MD) is a common congenital ileal diverticulum. Whilst mostly asymptomatic, 4-9% develop complications, such as small bowel obstruction, diverticulitis or bleeding. In 1933, Charles Mayo wrote that MD is 'frequently suspected, often looked for and seldom found', and it continues to pose a diagnostic challenge today.
View Article and Find Full Text PDFCumulative live birth rates of 31 478 untested embryos from 11 463 women challenge traditional recurrent implantation failure definitions.
Hum Reprod
March 2025
Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Study Question: Is there evidence of a plateau in the cumulative live birth rate (cLBR) after a certain number of consecutive transfers of untested embryos?
Summary Answer: In our cohort of 11 463 women, the cLBR continues to increase with each additional transfer of an untested embryo, reaching 68.3% after six blastocyst transfers and 78.0% after 10 blastocyst transfers.
Depth of Response From Fixed-Duration Treatment Is Associated With Superior Survival in Waldenstrom Macroglobulinemia.
Am J Hematol
March 2025
Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
As the treatment paradigm for Waldenström macroglobulinemia (WM) continues to evolve, the debate surrounding the prioritization of depth of response versus disease control as therapeutic goals gains significant relevance. However, the impact of depth of response from fixed-duration therapy on overall survival (OS) was unclear. This multicenter study evaluated the prognostic impact of depth of response using a landmark survival analysis.
View Article and Find Full Text PDFWhat you saw a while ago determines what you see now: Extending awareness priming to implicit behaviors and uncovering its temporal dynamics.
Cognition
March 2025
Research Group Neural Circuits, Consciousness and Cognition, Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany; Predictive Brain Department, Research Center One Health Ruhr, Ruhr-Universität Bochum, Germany.
Past experiences influence how we perceive and respond to the present. A striking example is awareness priming, in which prior conscious perception enhances visibility and discrimination of subsequent stimuli. In this partially pre-registered study, we address a long-standing debate and broaden the scope of awareness priming by demonstrating its effects on implicit motor responses.
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