AI Article Synopsis
- * Traditional methods for accurately typing HLA genes with short-read sequencing data have been challenging due to the similarities in the gene sequences.
- * A new algorithm called xHLA has been developed that achieves nearly perfect accuracy in typing HLA genes in just a few minutes on a standard desktop computer.
Article Abstract
The HLA gene complex on human chromosome 6 is one of the most polymorphic regions in the human genome and contributes in large part to the diversity of the immune system. Accurate typing of HLA genes with short-read sequencing data has historically been difficult due to the sequence similarity between the polymorphic alleles. Here, we introduce an algorithm, xHLA, that iteratively refines the mapping results at the amino acid level to achieve 99-100% four-digit typing accuracy for both class I and II HLA genes, taking only [Formula: see text]3 min to process a 30× whole-genome BAM file on a desktop computer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544337 | PMC |
| http://dx.doi.org/10.1073/pnas.1707945114 | DOI Listing |
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