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Experimental infection of Artibeus intermedius with a vampire bat rabies virus. | LitMetric

Experimental infection of Artibeus intermedius with a vampire bat rabies virus.

Comp Immunol Microbiol Infect Dis

Laboratorio de Rabia, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico. Electronic address:

Published: June 2017

AI Article Synopsis

  • A study was conducted on 35 great fruit-eating bats (Artibeus intermedius) using vampire bat rabies isolates to understand their response to the virus.
  • Prior to infection, no bats had rabies antibodies, but post-infection results showed high antibody levels in 34 bats, indicating a possible immune response or previous exposure.
  • One bat died without showing clinical signs but tested positive for rabies, while others showed no symptoms, suggesting this species may have low susceptibility to the virus, impacting their survival in the wild.

Article Abstract

Experimental infection of Artibeus intermedius, the great fruit-eating bat, was performed with vampire bat rabies isolates. Bats (n=35) were captured in the wild and quarantined prior to experimental infection. No rabies antibodies were detected by rapid fluorescent focus inhibition test (RFFIT) prior to infection. Three doses of rabies virus (RV) and three different routes of infection were used. One out of 35 bats died without showing any clinical signs at day 14 and was positive for rabies. None of the 34 other bats showed clinical signs for rabies, but high antibody titers were detected post-inoculation, suggesting either innate immune response to the vampire bat rabies virus or possible pre-exposure to RV and inoculation leading to a booster effect. Rabies virus was detected by hemi-nested RT-PCR (hnRT-PCR) in the brain (n=3), stomach (n=1) of bats that were negative by immunofluorescence and that survived rabies infection. The bat that died on day 14 was positive by hnRT-PCR on the brain, heart and liver. These results suggest that either previous non-lethal exposure to RV or natural low susceptibility to vampire bat viruses somehow protected Artibeus intermedius from clinical rabies infection leading to a marginal lethality effect on this bats species population in the wild.

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Source
http://dx.doi.org/10.1016/j.cimid.2017.05.008DOI Listing

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