AI Article Synopsis
- The study investigates the role of the human gut in the presence of Burkholderia pseudomallei, the bacteria that causes melioidosis.
- The research was conducted in Northeast Thailand, where stool and rectal swab samples were taken from melioidosis patients as well as from control patients without infections.
- The findings reveal that a small percentage of melioidosis patients shed the bacteria, but it was not found in control groups, suggesting that gut colonization in healthy individuals is uncommon.
Article Abstract
Background: Little is known about the involvement of the human gut in carriage and disease associated with Burkholderia pseudomallei, the cause of melioidosis.
Methods: A hospital-based study was conducted in Northeast Thailand to culture stools or rectal swabs from patients with melioidosis, stools from controls with non-infectious diseases, and gastric biopsies from patients undergoing routine endoscopic investigation.
Results And Conclusion: B. pseudomallei was isolated from 9/83 (11%) stools and 9/58 (16%) rectal swabs from 141 patients with melioidosis. All stools from 244 control patients and 799 gastric biopsies from 395 patients with no evidence of melioidosis were culture negative for B. pseudomallei. It is not uncommon for melioidosis patients to shed B. pseudomallei in stool. Colonization of the gut of individuals without signs and symptoms of melioidosis may be rare.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092629 | PMC |
| http://dx.doi.org/10.1093/trstmh/trx031 | DOI Listing |
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