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Olanzapine versus quetiapine in critically ill patients with hyperactive delirium: Protocol for a multicentre, cluster-randomised, double-crossover, pragmatic clinical trial (CALM-ICU).
Crit Care Resusc
December 2024
Department of Intensive Care, The Royal Melbourne Hospital, Melbourne, Australia.
Background: Patients in the intensive care unit (ICU) frequently develop hyperactive delirium, which may be accompanied by behaviour that increases clinical risks to themselves as well as other patients and staff. There is a paucity of evidence to inform the urgent enteral administration of antipsychotic drugs to treat such hyperactive delirium and behavioural disturbances.
Objective: The aim of this study is to test the efficacy and safety of administering enteral olanzapine when compared to quetiapine in critically ill patients with hyperactive delirium.
Contemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocrit Care
January 2025
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Background: Neuroleptic malignant syndrome (NMS) is a psychiatric-neurologic emergency that may require intensive care management. There is a paucity of information about NMS as a critical illness. We reviewed the Mayo Clinic experience.
View Article and Find Full Text PDFPolypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine.
Z Gerontol Geriatr
January 2025
Orthopedics and Trauma Surgery, University Hospital Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Article Synopsis
- Polypharmacy, particularly the anticholinergic burden from medications, increases the risk of delirium in older patients due to changes in their cholinergic system.
- A prospective study of 421 patients evaluated preoperative medications and found that certain drug categories, including antidepressants and Parkinson's medication, significantly raised delirium risk, with a notable correlation to anticholinergic burden.
- The study emphasizes the importance of standardized medication documentation and suggests integrating the anticholinergic burden score into preoperative geriatric assessments to better identify patients at risk for delirium.
Practices and attitudes of adult psychiatrists regarding methamphetamine-associated psychotic disorder: an internet based survey conducted in Turkey.
BMC Health Serv Res
January 2025
Department of Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
Background: Many variables may affect approaches of psychiatrists to methamphetamine-associated psychotic disorder (MAP) treatment. This study was aimed to reach adult psychiatrists actively practicing in Turkey through an internet-based survey and to determine their practices and attitudes to MAP treatment.
Methods: In this internet-based study, participants were divided into three groups based on their answers: Those who do not follow-up any MAP patient were group 1 (n = 78), partially involved in the treatment process of at least one patient diagnosed with MAP were group 2 (n = 128), completely involved in the treatment process of at least one patient diagnosed with MAP were group 3 (n = 202).
Effect of prophylactic perphenazine on delirium after extubation in severe acute pancreatitis.
Eur J Med Res
November 2024
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Article Synopsis
- Severe acute pancreatitis (SAP) can lead to delirium after invasive mechanical ventilation (IMV), impacting patient recovery negatively.
- A study of 40 SAP patients found that prophylactic use of perphenazine reduced delirium incidence from 22.5%, highlighting its potential benefit.
- Fentanyl use was identified as a risk factor for delirium, and patients with delirium experienced longer hospital stays compared to non-delirium patients.
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