Background: We investigated the effects of acrobatic training (AT) on expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits in the sensorimotor cortex and striatum after intracerebral hemorrhage (ICH).
Methods: Male Wistar rats were divided into 4 groups: ICH without AT (ICH), ICH with AT (ICH + AT), sham operation without AT (SHAM), and sham operation with AT (SHAM + AT). ICH was induced by collagenase injection into the left striatum. The ICH + AT group performed 5 acrobatic tasks daily on days 4-28 post ICH. Forelimb sensorimotor function was evaluated using the forelimb placing test. On days 14 and 29, mRNA expression levels of AMPAR subunits GluR1-4 were measured by real-time reverse transcription-polymerase chain reaction.
Results: Forelimb placing test scores were significantly higher in the ICH + AT group than in the ICH group. Expression levels of all AMPAR subunit mRNAs were significantly higher in the ipsilateral sensorimotor cortex of rats in the ICH + AT group than in that of rats in the ICH group on day 29. GluR3 and GluR4 expression levels were reduced in the ipsilateral striatum of rats in the ICH group compared with that of rats in the SHAM group on day 14.
Conclusions: These changes may play a critical role in motor skills training-induced recovery after ICH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.05.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis.
Sci Rep
January 2025
Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
This study aims to establish an imitation task of multi-finger haptics in the context of regular grasping and regrasping processes during activities of daily living. A video guided the 26 healthy, right-handed volunteers through the three phases of the task: (1) fixation of a hand holding a cuboid, (2) observation of the sensori-motor manipulation, (3) imitation of that motor action. fMRI recorded the task; graph analysis of the acquisitions revealed the associated functional cerebral connectivity patterns.
View Article and Find Full Text PDFAPOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice.
Commun Biol
January 2025
School of Psychology and Sussex Neuroscience, University of Sussex, Brighton, UK.
Reduced cerebral blood flow occurs early in the development of Alzheimer's disease (AD), but the factors producing this reduction are unknown. Here, we ask whether genetic and lifestyle risk factors for AD-the ε4 allele of the Apolipoprotein (APOE) gene, and physical activity-can together produce this reduction in cerebral blood flow which leads eventually to AD. Using in vivo two-photon microscopy and haemodynamic measures, we record neurovascular function from the visual cortex of physically active or sedentary mice expressing APOE3 and APOE4 in place of murine APOE.
View Article and Find Full Text PDFPreterm Neonates Exhibit a "Catch-Up" Pattern in Motor Development During the Neonatal Period: A Diffusion Tensor Imaging Study.
Pediatr Neurol
January 2025
Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence, Xi'an, China. Electronic address:
Background: Preterm infants are at high risk for subsequent neurodevelopmental disability. Early developmental characterization of brain and neurobehavioral function is critical for identifying high-risk infants. This study aimed to elucidate the early evolution of sensorimotor function in preterm neonates by exploring postnatal age-related changes in the brain white matter (WM) and neurobehavioral abilities.
View Article and Find Full Text PDFDissociable ventral and dorsal sensorimotor functional circuits linking the hypomanic personality traits to aggression via behavioral inhibition system.
Int J Clin Health Psychol
January 2025
Faculty of Psychology, Tianjin Normal University, Tianjin, 300387, China.
Article Synopsis
- Hypomanic personality traits (HPT) are linked to higher risk for psychiatric disorders like bipolar disorder and are associated with aggressive behaviors, yet the underlying neuropsychological mechanisms are not fully understood.
- The study used psychometric network analysis to identify key factors (Behavioral Inhibition System and mood volatility) that connect HPT to aggression, finding that mood volatility positively correlates with aggression, with BIS acting as a mediator.
- Further imaging studies revealed distinct functions of the dorsal and ventral sensorimotor cortices in processing rewards, and resting-state imaging confirmed these regions' connections to different brain networks, highlighting the importance of these circuits in mediating the relationship between mood volatility, aggression, and BIS.
Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training.
Front Hum Neurosci
January 2025
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Background: Bimanual motor training is an effective neurological rehabilitation strategy. However, its use has rarely been investigated in patients with paralysis caused by spinal cord injury (SCI). Therefore, we conducted a case study to investigate the effects of robot-assisted task-oriented bimanual training (RBMT) on upper limb function, activities of daily living, and movement-related sensorimotor activity in a patient with SCI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!