AI Article Synopsis
- * Induced pluripotent stem cell (iPSC) technology is being explored as a method to identify important cancer-related genes linked to CSCs and to understand how these genes interact with their environment.
- * Recent advancements in iPSC technology show promise for clinical applications, including drug screening and insights into how CSCs contribute to cancer initiation and progression.
Article Abstract
The cancer stem cell (CSC) hypothesis is an evolving concept of oncogenesis that has recently gained wide acceptance. By definition, CSCs exhibit continuous proliferation and self-renewal, and they have been proposed to play significant roles in oncogenesis, tumor growth, metastasis, chemoresistance, and cancer recurrence. The reprogramming of cancer cells using induced pluripotent stem cell (iPSC) technology is a potential strategy for the identification of CSC-related oncogenes and tumor-suppressor genes. This technology has some advantages for studying the interactions between CSC-related genes and the cancer microenvironment. This approach may also provide a useful platform for studying the mechanisms of CSCs underlying cancer initiation and progression. The present review summarizes the recent advances in cancer cell reprogramming using iPSC technology and discusses its potential clinical use and related drug screening.
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| http://dx.doi.org/10.21873/anticanres.11703 | DOI Listing |
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