Natural Antibodies: Next Steps Toward Translational Investigation.

Natural antibodies have diverse functions in maintaining immune homeostasis and in the regulation of autoimmune response. Yet there might be other important functions of natural antibodies for human medicine such as the ability of natural antibodies to shape and induce antibody immune responses. I propose that natural antibodies, present in IVIG, could be used to prevent autoimmune reactions and to enhance the immune response to vaccination.