In recent years, giant viruses belonging to the family Mimiviridae have been proposed to be infectious agents in humans. In this work we provide evidence of mimivirus genome and neutralizing antibodies detection in humans.
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Pacmanvirus isolated from the Lost City hydrothermal field extends the concept of transpoviron beyond the family Mimiviridae.
ISME J
January 2025
Information Génomique & Structurale, Unité Mixte de Recherche 7256, Aix-Marseille University, Centre National de la Recherche Scientifique, IMM, IM2B, 13288, Marseille Cedex 9, France.
The microbial sampling of submarine hydrothermal vents remains challenging, with even fewer studies focused on viruses. Here we report the first isolation of a eukaryotic virus from the Lost City hydrothermal field, by co-culture with the laboratory host Acanthamoeba castellanii. This virus, named pacmanvirus lostcity, is closely related to previously isolated pacmanviruses (strains A23 and S19), clustering in a divergent clade within the long-established family Asfarviridae.
View Article and Find Full Text PDFThe HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions.
DNA Repair (Amst)
January 2025
Agriculture and Marine Science Program, Graduate School of Integrated Arts and Science, Kochi University, Nankoku, Kochi 783-8502, Japan; Agricultural Science, Graduate School of Integrated Arts and Science, Kochi University, Nankoku, Kochi 783-8502, Japan. Electronic address:
Most giant viruses including Mimiviridae family build large viral factories within the host cytoplasms. These giant viruses are presumed to possess specific genes that enable the rapid and massive replication of their large double-stranded DNA genomes within viral factories. It has been revealed that a functionally uncharacterized protein, MutS7, is expressed during the operational phase of the viral factory.
View Article and Find Full Text PDFIntroduction: Metagenomic research has allowed the identification of numerous viruses present in the human body. Viruses may significantly increase the likelihood of developing intrauterine fetal growth restriction (FGR). The goal of this study was to examine and compare the virome of normal and FGR placentas using proteomic techniques.
View Article and Find Full Text PDFAcanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection.
Sci Rep
October 2024
Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Article Synopsis
- Mimivirus bradfordmassiliense is a giant virus that infects Acanthamoeba species, leading to significant changes in the host's gene expression during infection.
- Long- and short-read sequencing techniques revealed a complex transcriptome of the host, showing a total of 22,604 transcripts and major downregulation in genes involved in crucial cellular functions like cytoskeleton stability and DNA synthesis, indicating cell cycle arrest.
- The virus itself exhibited dynamic gene expression trends, with early stages focusing on DNA-related processes and later stages emphasizing lipid metabolism and protease activity, suggesting extensive disruption of the host's cellular organization.
Giant viruses inhibit superinfection by downregulating phagocytosis in .
J Virol
October 2024
Laboratório de Vírus, Instituto de Ciências Biológicas, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Article Synopsis
- Superinfection inhibition occurs when certain viruses prevent additional viruses from entering infected host cells, ensuring the genetic dominance of the first virus.
- Research has explored this phenomenon in giant amoeba-infecting viruses, specifically mimivirus and moumouvirus, which have shown the ability to inhibit new infections, while megavirus does not.
- The study highlights that mimivirus and moumouvirus disrupt amoebic phagocytosis, altering host cell behavior, whereas megavirus allows continued entry of new virions, indicating significant differences in viral-host interactions despite their evolutionary similarities.
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