Association of the Promoter (rs3730485) Polymorphism in the Gene with Breast Cancer in a Mexican Population.

Introduction: The gene plays an important role in tumorigenesis. The data on the promoter polymorphism in the gene have revealed associations with cancer.

Material And Methods: We examined the role of the polymorphism through a comparison of the genotypes of 345 healthy Mexican women with those of 742 Mexican women with breast cancer (BC).

Results: The genotype frequencies of the polymorphism in controls and patients with BC were 64% and 55.5% for , 32% and 31.5% for , and 4% and 13% for , respectively. The obtained odds ratio (OR) was 3.26, with a 95% confidence interval (95% CI) of 1.86-5.72 and =0.0001, for the genotype. An association was evident when we examined the distribution of the genotype in patients with elevated levels of transaminase SGPT (OR=2.268; 95% CI=1.40-3.65; =0.0001). Additionally, we observed an association of the genotypes in menopausal patients with BC with the following characteristics: tobacco consumption (OR = 1.93, 95% CI = 1.07-3.4, =0.025), pregnancy loss (OR=2.44, 95% CI=1.37-4.35, =0.0024), obesity (I-IV) (OR=1.8, 95% CI=1.1-2.9, = 0.018), and elevated serum glucose levels (OR=3.72, 95% CI=2.0-6.85, =0.0001).

Conclusions: The polymorphism was associated with BC susceptibility, particularly in menopausal patients with BC who reported tobacco consumption, pregnancy loss, obesity and high glucose levels in the analyzed Mexican population.