AI Article Synopsis
- Autophagy, which is the process of degrading cellular components, is crucial for development and maintaining human health, but it's mainly seen as an internal cell mechanism.
- Researchers discovered that the protein Mcr in fruit flies (Drosophila) influences autophagy not just within a cell, but also in surrounding cells during developmental cell death and inflammation.
- This process is linked to the immune receptor Draper and shows that one cell can control the autophagy of neighboring cells through ancient immune signaling pathways, particularly impacting macrophage activity during wound healing.
Article Abstract
Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533186 | PMC |
| http://dx.doi.org/10.1016/j.cell.2017.06.018 | DOI Listing |
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