Arh Hig Rada Toksikol
.
Published: June 2017
This study was designed to investigate the in vivo effects of ochratoxin A (OTA) and/or lycopene on the levels of selenium, zinc, and copper in the liver, kidneys, and testes of male Sprague-Dawley rats. The rats were treated with OTA (0.5 mg kg-1 day-1) and/or lycopene (5 mg kg-1 day-1) by gavage for 7 or 14 days. Trace element levels were measured by atomic absorption spectrometry. OTA significantly lowered selenium (20 % in the liver, 17 % in the kidney, and 40 % in the testis), zinc (24 % in the liver, 23 % in the kidney, and 26 % in the testis), and copper levels (40 % in the liver and 10 % in the kidney). Lycopene alone did not affect the trace element levels in any of the organs. In combination with OTA, however, it significantly restored liver, kidney, and testis selenium and zinc levels compared to the group treated with OTA alone. Our results have confirmed that depletion of trace elements in different organs is one of the mechanisms of action of OTA. They also suggest that lycopene interferes with this depleting effect and restores trace element levels, the implications of which need to be further investigated.
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http://dx.doi.org/10.1515/aiht-2017-68-2905 | DOI Listing |
Proc Natl Acad Sci U S A
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Department of Chemistry, Princeton University, Princeton, NJ 08544.
Chemical communication between marine bacteria and their algal hosts drives population dynamics and ultimately determines the fate of major biogeochemical cycles in the ocean. To gain deeper insights into this small molecule exchange, we screened niche-specific metabolites as potential modulators of the secondary metabolome of the roseobacter, . Metabolomic analysis led to the identification of a group of cryptic lipids that we have termed roseoceramides.
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Department of Environmental Medicine, School of Medicine, Chongqing University, Chongqing, China.
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Department of Botany, Bacha Khan University, Charsadda, Charsadda, 24420, Khyber Pakhtunkhwa, Pakistan.
Wastewater is commonly contaminated with many pharmaceutical pollutants, so an efficient purification method is required for their removal from wastewater. In this regard, an innovative tertiary Se/SnO@CMC/Fe-GA nanocomposite was synthesized through encapsulation of metal organic frameworks (Fe-glutaric acid) onto Se/SnO-embedded-sodium carboxy methyl cellulose matrix to thoroughly evaluate its effectiveness for adsorption of levofloxacin drug from wastewater. The prepared Se/SnO@CMC/Fe-GA nanocomposite was analyzed via UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermo gravimetric analysis (TGA), energy dispersive X-ray (EDX), and X-ray diffraction (XRD) to valuate optical property, size, morphology, thermal stability, and chemical composition.
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The Krieger Eye Research Laboratory, Bruce and Ruth Faculty of Medicine, Technion-Institute of Technology, Haifa 3525433, Israel.
Cobalt is a trace element, crucial for red blood cell formation and neurological function. Cobalt toxicity is often only diagnosed after severe manifestations, including visual impairment. We aimed to investigate whether optical coherence tomography (OCT) and magnetic resonance imaging (MRI) can effectively detect cobalt-induced ocular toxicity in a murine model.
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School of Basic Medicine, Institute of Brain Science and Disease, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Brain Diseases, Qingdao University, Qingdao, Shandong, 266071, China. E-mail:
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function; however, its abnormal accumulation is also implicated in various neurological disorders. The olfactory bulb (OB), an early target in neurodegenerative diseases, acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles. This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate (FAC).
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