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Lyophilized powder of calf bone marrow hydrolysate liposomes improved renal anemia: In vitro and in vivo evaluation.
PLoS One
December 2024
Department of Research and Development, Jinan Perfect Biological Technology Co., LTD, Jinan, Shandong, China.
This study aimed to find whether oral administration of calf bone marrow hydrolysate liposomes (CBMHL) can improve renal anemia. Calf bone marrow was defatted, papain hydrolyzed, liposomalized and lyophilized. Its hematopoietic ability was proved by the colony formation experiment of umbilical cord blood hematopoietic stem cells in vitro.
View Article and Find Full Text PDFEPO modified MSCs protects SH-SY5Y cells against ischemia/hypoxia-induced apoptosis via REST-dependent epigenetic remodeling.
Sci Rep
October 2024
Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) is a condition causing brain injury from lack of oxygen and blood flow, mainly seen in newborns but can also affect adults; mesenchymal stem cell (MSC) therapies show promise in improving brain function after HIE.
- Research indicates that human umbilical cord MSCs (hUC-MSCs) express more erythropoietin (EPO) the longer they are exposed to hypoxia, and EPO can be secreted to aid in neuroprotection.
- The study employs techniques like flow cytometry, RNA sequencing, and CRISPR to explore how EPO-MSCs could reduce inflammation and apoptosis in brain cells after HIE, aiming
TMEM56 deficiency impairs the haem metabolism and cell cycle progression during human erythropoiesis.
Br J Haematol
November 2024
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Article Synopsis
- * The researchers found that when TMEM56 is lost, it disrupts the production of haem (a component crucial for hemoglobin) and negatively affects the differentiation of erythroid cells derived from umbilical cord blood stem cells.
- * In mouse models, deleting the TMEM56 gene in the erythroid lineage led to problems with erythroid progenitor cells in the bone marrow, highlighting its essential function in maintaining healthy red blood cell production and suggesting it might be a new target for treating blood disorders.
Silk fibroin/chitosan/montmorillonite sponge dressing: Enhancing hemostasis, antimicrobial activity, and angiogenesis for advanced wound healing applications.
Int J Biol Macromol
November 2024
Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin si, Gyeonggi do 17104, Republic of Korea. Electronic address:
Open wounds present a significant challenge in healthcare, requiring careful management to prevent infection and promote wound healing. Advanced wound dressings are critical need to enhance their hemostatic capabilities, antimicrobial properties, and ability to support angiogenesis and sustained moisture for optimal healing. This study introduces a flexible hemostatic dressing designed for open wounds, integrating chitosan (CS) for hemostasis and biocompatibility, silk fibroin (SF) for mechanical strength, and montmorillonite (MMT) for enhanced drug transport.
View Article and Find Full Text PDFMulti-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre-Pregnancy Obesity.
medRxiv
August 2024
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI.
Background: Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the transgenerational effect of maternal obesity, we conducted a multi-omics study, using DNA methylation and gene expression in the CD34+/CD38-/Lin- umbilical cord blood hematopoietic stem cells (uHSCs) and metabolomics of the cord blood, all from a multi-ethnic cohort (n=72) from Kapiolani Medical Center for Women and Children in Honolulu, Hawaii (collected between 2016 and 2018).
Results: Differential methylation (DM) analysis unveiled a global hypermethylation pattern in the maternal pre-pregnancy obese group (BH adjusted p<0.
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