AI Article Synopsis
- The study details an iridium-catalyzed method for synthesizing pyrrole-annulated medium-sized-ring compounds through a series of reactions, including allylic dearomatization and retro-Mannich processes.
- Various seven- and eight-membered-ring products were successfully created under mild conditions, yielding moderate to good results with high enantioselectivity.
- The developed method offers an efficient approach to access compounds that are commonly found in natural products and have biological significance.
Article Abstract
Enantioselective synthesis of pyrrole-annulated medium-sized-ring compounds by an iridium-catalyzed allylic dearomatization/retro-Mannich/hydrolysis sequence is presented. Various substituted pyrrole-annulated seven- and eight-membered-ring products were obtained under mild reaction conditions with moderate to good yields and excellent enantioselectivity. Additionally, these products contain a scaffold widely distributed in natural products and biologically active compounds. The current method provides a convenient way for accessing such pyrrole-anuulated medium-sized-ring compounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201705068 | DOI Listing |
Publication Analysis
Top Keywords
medium-sized-ring compounds
12
enantioselective synthesis
8
synthesis pyrrole-annulated
8
pyrrole-annulated medium-sized-ring
8
iridium-catalyzed enantioselective
4
compounds
4
compounds enantioselective
4
compounds iridium-catalyzed
4
iridium-catalyzed allylic
4
allylic dearomatization/retro-mannich/hydrolysis
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!