Biomed Opt Express
KIOS Research Center, Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus.
Published: March 2017
The size-dependent spectral variations, predicted by Mie theory, have already been considered as a contrast enhancement mechanism in optical coherence tomography. In this work, a new spectroscopic metric, the bandwidth of the correlation of the derivative, was developed for estimating scatterer size which is more robust and accurate compared to existing methods. Its feasibility was demonstrated using phantoms containing polystyrene microspheres as well as images of normal and cancerous human colon. The results are very promising, suggesting that the proposed metric could be utilized for measuring nuclear size distribution, a diagnostically valuable marker, in human tissues.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480567 | PMC |
http://dx.doi.org/10.1364/BOE.8.001598 | DOI Listing |
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