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Spatial transcriptomic clocks reveal cell proximity effects in brain ageing.
Nature
December 2024
Department of Genetics, Stanford University, Stanford, CA, USA.
Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk. Brain ageing is complex and is accompanied by many cellular changes. Furthermore, the influence that aged cells have on neighbouring cells and how this contributes to tissue decline is unknown.
View Article and Find Full Text PDFThe CALERIE Genomic Data Resource.
Nat Aging
December 2024
Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial.
View Article and Find Full Text PDFTelomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice.
Aging Cell
December 2024
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
While previous research has demonstrated the therapeutic efficacy of telomerase reverse transcriptase (TERT) overexpression using adeno-associated virus and cytomegalovirus vectors to combat aging, the broader implications of TERT germline gene editing on the mammalian genome, proteomic composition, phenotypes, lifespan extension, and damage repair remain largely unexplored. In this study, we elucidate the functional properties of transgenic mice carrying the Tert transgene, guided by precise gene targeting into the Rosa26 locus via embryonic stem (ES) cells under the control of the elongation factor 1α (EF1α) promoter. The Tert knock-in (TertKI) mice harboring the EF1α-Tert gene displayed elevated telomerase activity, elongated telomeres, and extended lifespan, with no spontaneous genotoxicity or carcinogenicity.
View Article and Find Full Text PDFDisagreement on foundational principles of biological aging.
PNAS Nexus
December 2024
Insilico Medicine, Cambridge, MA 02138, USA.
Article Synopsis
- - A survey of aging researchers revealed significant disagreement on key questions about aging, such as its definition, causes, onset, and rejuvenation, indicating a lack of consensus in the field.
- - Researchers have varying interpretations of what constitutes "aging," leading to different experimental approaches and priorities, which complicates the understanding and study of the aging process.
- - The findings highlight the necessity for clearer definitions and targeted goals within aging research, as well as strategies to address ongoing disagreements, in hopes of advancing the field.
The Digital Divide and Cognitive Disparities Among Older Adults: Community-Based Cohort Study in China.
J Med Internet Res
November 2024
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Background: The widespread adoption of information and communication technologies (ICTs) further deepens disparities in resource access, particularly among the aging population. However, the relationship between these factors and their resulting impact on cognitive abilities remains uncertain.
Objective: This study aims to investigate the potential impact of the digital divide on individuals' cognitive function and its association with the development and reversion of mild cognitive impairment (MCI).
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