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Recent advances in rectal cancer treatment - are we on the right track?
Ups J Med Sci
March 2024
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Background: Staging and treatment of rectal cancer have evolved over several decades with considerably fewer locoregional recurrences but no marked improved survival since systemic recurrence risks remain virtually unchanged. This development will briefly be summarised followed by a thorough discussion of two recent developments.
Methods: A systematic approach towards the literature is aimed at focusing on organ preservation and the delivery of all non-surgical treatments prior to surgery or total neoadjuvant treatment (TNT).
AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
J Hepatol
December 2023
Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA. Electronic address:
Background & Aims: Alpha-fetoprotein (AFP) predicts hepatocellular carcinoma (HCC) recurrence after liver transplant (LT) but remains an imperfect biomarker. The role of DCP (des-gamma-carboxyprothrombin) and AFP-L3 (AFP bound to Lens culinaris agglutinin) in predicting HCC recurrence remains incompletely characterized. AFP-L3 and DCP could identify patients at high risk of post-transplant HCC recurrence and serve as liver transplant exclusion criteria to defer transplant until patients receive additional risk-reducing pre-transplant locoregional therapy.
View Article and Find Full Text PDFNeoadjuvant Therapy in the Post-German Rectal Trial Era: Making Sense in the Absence of Consensus.
Pract Radiat Oncol
January 2023
Department of Radiation Oncology, Stanford University, Stanford, California. Electronic address:
Trimodality therapy per the German Rectal Trial has led to excellent locoregional outcomes for locally advanced rectal cancer. Recent efforts have shifted toward improving distant control and health-related quality of life in this disease. To this end, total neoadjuvant therapy has become an increasingly used approach in which most, if not all, chemotherapy is delivered before surgery to improve compliance and to address micrometastases early.
View Article and Find Full Text PDFSymptom-based remote assessment in post-treatment head and neck cancer surveillance: A prospective national study.
Clin Otolaryngol
September 2022
Head and Neck Unit, Royal Marsden Hospital, London, UK.
Objectives: To report the incidence of locoregional recurrence in head and neck cancer (HNC) patients under surveillance following treatment undergoing symptom-based remote assessment.
Design: A 16-week multicentre prospective cohort study.
Setting: UK ENT departments.
Management of arterial dissections in 12 patients during transarterial chemoembolization and yttrium-90 selective internal radiotherapy for primary and secondary liver tumours.
Abdom Radiol (NY)
April 2021
Department of Vascular and Interventional Radiology, Singapore General Hospital, Singapore, 169608, Singapore.
Objective: To describe rates and management strategies of arterial dissections in transarterial chemoembolization (TACE) and Yttrium-90 selective internal radiotherapy (Y SIRT) for primary and secondary liver tumours.
Materials And Methods: This retrospective review included 1377 hepatic angiographies between May 2010 and June 2015 in a single centre for TACE and Y SIRT of liver tumours. The angiogram results, management, treatment outcomes and follow-up angiography/imaging findings were recorded.
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