Nano-graphene oxide (GO) and its functionalized derivatives have aroused a great interest for drug delivery, tissue engineering and photothermal cancer therapy, but their biocompatibility has not yet been fully assessed. The aim of the present study was to evaluate the proliferation and differentiation of MC3T3-E1 pre-osteoblasts after the uptake of GO nanosheets (c.a. 400nm), functionalized with poly(ethylene glycol-amine) (PEG) and labelled with fluorescein isothiocyanate (FITC). Significant proliferation decrease and apoptosis increase were observed 3days after incorporation of FITC-PEG-GO by MC3T3-E1 cells. However, alterations on healthy pre-osteoblast differentiation into cells exhibiting osteoblast phenotype were not observed, as they showed normal alkaline phosphatase levels and matrix mineralization 12days after nanosheet uptake. The results suggest that 40μg/mL concentrations of these nanosheets would not affect the differentiation of healthy pre-osteoblasts, thus these PEG-GO nanosheets have potential to be used for biomedical applications after their internalization, as the induction of local hyperthermia on bone cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2017.06.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biocompatible 2D Material Inks Enabled by Supramolecular Chemistry: From Synthesis to Applications.
Acc Chem Res
January 2025
Department of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom.
ConspectusThe emergence of two-dimensional (2D) materials, such as graphene, transition-metal dichalcogenides (TMDs), and hexagonal boron nitride (h-BN), has sparked significant interest due to their unique physicochemical, optical, electrical, and mechanical properties. Furthermore, their atomically thin nature enables mechanical flexibility, high sensitivity, and simple integration onto flexible substrates, such as paper and plastic.The surface chemistry of a nanomaterial determines many of its properties, such as its chemical and catalytic activity.
View Article and Find Full Text PDFSequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy.
Acc Chem Res
January 2025
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
ConspectusStructural DNA nanotechnology offers a unique self-assembly toolbox to construct soft materials of arbitrary complexity, through bottom-up approaches including DNA origami, brick, wireframe, and tile-based assemblies. This toolbox can be expanded by incorporating interactions orthogonal to DNA base-pairing such as metal coordination, small molecule hydrogen bonding, π-stacking, fluorophilic interactions, or the hydrophobic effect. These interactions allow for hierarchical and long-range organization in DNA supramolecular assemblies through a DNA-minimal approach: the use of fewer unique DNA sequences to make complex structures.
View Article and Find Full Text PDFLysozyme-coated nanoparticles for active uptake and delivery of synthetic RNA and plasmid-encoded genes in plants.
Nat Plants
January 2025
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.
Nanoparticle-mediated delivery of nucleic acids and proteins into intact plants has the potential to modify metabolic pathways and confer desirable traits in crops. Here we show that layered double hydroxide (LDH) nanosheets coated with lysozyme are actively taken up into the root tip, root hairs and lateral root junctions by endocytosis, and translocate via an active membrane trafficking pathway in plants. Lysozyme coating enhanced nanosheet uptake by (1) loosening the plant cell wall and (2) stimulating the expression of endocytosis and other membrane trafficking genes.
View Article and Find Full Text PDFStructural transformation from a 3D hydrophilic pillared-layered framework to 2D hydrophobic MOF nanosheets through ligand replacement exfoliation.
Dalton Trans
December 2024
Department of Applied Chemistry, National Chi Nan University, Nantou 545, Taiwan.
Article Synopsis
- - A new metal-organic framework (MOF), labeled as 1, was created with a unique structure and showed significant CO gas adsorption capacities at low temperatures.
- - By immersing the original MOF in 4-picoline, researchers produced nanosheets (1-ns) that have a different, two-dimensional structure, with thorough characterization confirming their properties.
- - The 1-ns exhibited better electrochemical performance compared to the original 3D structure (1) and showed potential for oil/water separation due to its hydrophobic surfaces, highlighting diverse applications for these materials.
Calcium-atom-modified boron phosphide (BP) biphenylene as an efficient hydrogen storage material.
RSC Adv
December 2024
Faculty of Engineering and Technology, Multimedia University Jalan Ayer Keroh Lama 75450 Melaka Malaysia.
Porous nanosheets have attracted significant attention as viable options for energy storage materials because of their exceptionally large specific surface areas. A recent study (, 2024, , 33-39) has demonstrated that Li/Na-metalized inorganic BP-biphenylene (b-BP) and graphenylene (g-BP) analogues possess suitable functionalities for hydrogen (H) storage. Herein, we evaluate the H storage performance of alkaline earth metal (AEM = Be, Mg, Ca)-decorated b-BP and g-BP structures based on first-principles density functional theory (DFT) calculations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!