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Long-Term Remission Rate of Type 2 Diabetes Following Bariatric Surgery: A Retrospective Cohort Study in Adult Patients in Riyadh, Saudi Arabia.
Cureus
January 2025
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Article Synopsis
- Type 2 Diabetes Mellitus (T2DM) is a prevalent chronic condition in Saudi Arabia, and while bariatric surgery is known to aid in weight loss and potentially induce remission, long-term effects specific to the Saudi population are not well understood.
- A retrospective study analyzed medical records of 74 Saudi adults who underwent bariatric surgery from 2016-2020, focusing on changes in Hemoglobin A1c (HbA1c) levels pre-and post-surgery and evaluating diabetes remission based on American Diabetes Association criteria.
- Results showed significant improvements in glycemic control, with mean HbA1c levels dropping from 8.70 to 6.76 after one year; however, only 27%
Tissue-resident NK cells do their own glandscaping.
J Exp Med
March 2025
Division of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
In this issue of JEM, Sparano et al. (https://doi.org/10.
View Article and Find Full Text PDFEnhancing the Immunotherapeutic Effect by IP-001 and Irreversible Electroporation in Mouse Oligometastatic Models of Pancreatic Adenocarcinoma.
Ann Surg Oncol
December 2024
Division of Surgical Oncology, Department of Surgery, School of Medicine, University of Louisville, Louisville, KY, USA.
Background: This study aimed to evaluate the immunotherapeutic effect of irreversible electroporation (IRE) and IP-001 in pancreatic adenocarcinoma with metastasis.
Methods: Orthotopic models of pancreatic adenocarcinoma with hepatic oligometastasis were established by implantation of tumor tissues (derived from Pan02 or KPC cells) size 2 mm into the pancreas and left liver lobe in C57BL/6J mice. One week after implantation, the tumor-burden mice were subjected to saline control, IRE, IP-001, and IRE+IP-001.
Using a two sample Mendelian randomization approach to explore the causal relationship between erectile dysfunction and lung function.
Transl Androl Urol
November 2024
Department of Urology, Innovation Institute for Integration of Medicine and Engineering, West China Hospital, Sichuan University, Chengdu, China.
Background: Recently, some observational studies have suggested potential associations between erectile dysfunction (ED) and respiratory function. However, the underlying biological mechanisms and causal relationships between ED and lung function require further investigation. This study aimed to explore the causalities between ED and lung function traits.
View Article and Find Full Text PDFCausal relationship between cathepsins and major salivary gland neoplasms: a bidirectional Mendelian randomization study.
Gland Surg
November 2024
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Background: Observational studies have suggested a potential link between cathepsins and major salivary gland neoplasms (MSGNs), but the causality of this relationship remains uncertain. Mendelian randomization (MR) is a significant genetic method that employs single nucleotide polymorphisms (SNPs) as instrumental variables (IVs). This approach reduces confounding effects, enabling the analysis of causal relationships between exposure traits and outcome diseases.
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