Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients with different forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Our preliminary results do not support the hypothesis that OLP may be triggered by MCPyV infection. Further studies are needed to evaluate the involvement of other human polyomaviruses in OLP pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmv.24887 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatiotemporal Spectroscopy of Fast Excited-State Diffusion in 2D Covalent Organic Framework Thin Films.
J Am Chem Soc
January 2025
Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 5-13, Munich 81377, Germany.
Covalent organic frameworks (COFs), crystalline and porous conjugated structures, are of great interest for sustainable energy applications. Organic building blocks in COFs with suitable electronic properties can feature strong optical absorption, whereas the extended crystalline network can establish a band structure enabling long-range coherent transport. This peculiar combination of both molecular and solid-state materials properties makes COFs an interesting platform to study and ultimately utilize photoexcited charge carrier diffusion.
View Article and Find Full Text PDFRe-exposition to ipilimumab plus nivolumab in metastatic Merkel cell carcinoma.
Front Immunol
December 2024
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Background: Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous malignancy. Immune checkpoint inhibition (ICI) with PD-(L)1 blockade has significantly improved treatment outcomes in metastatic disease. In patients with primary resistance to PD-(L)1 inhibition, a high overall response rate (ORR) of 50% to later-line ipilimumab plus nivolumab (IPI/NIVO) has been demonstrated.
View Article and Find Full Text PDFspatialGE is a User-Friendly Web Application that Facilitates Spatial Transcriptomics Data Analysis.
Cancer Res
December 2024
Children's Mercy Hospital, Kansas City, MO, United States.
Spatial transcriptomics (ST) is a powerful tool for understanding tissue biology and disease mechanisms. However, the advanced data analysis and programming skills required can hinder researchers from realizing of the full potential of ST. To address this, we developed spatialGE, a web application that simplifies the analysis of ST data.
View Article and Find Full Text PDFRare Case of Germline GATA2-Deficiency With Merkel Cell Carcinoma and Acute Myeloid Leukemia.
Cancer Rep (Hoboken)
December 2024
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background: Germline GATA2-deficiency usually manifests as immunodeficiencies and myeloid neoplasms and sometimes with dermatological diseases, including warts, panniculitis, and skin cancers.
Case: We report a 36-year-old woman with germline GATA2-deficiency who developed Merkel cell carcinoma followed by acute myeloid leukemia. Molecular analysis revealed a germline GATA2 S447R variant, not reported from the previous reported case, suggesting a potential association with Merkel cell carcinoma.
Prevalence of Human Polyomaviruses in Oral and Oropharyngeal Squamous Cell Carcinoma From Patients Treated at a Cancer Center in Sao Paulo, Brazil.
J Med Virol
December 2024
Postgraduate Program in Translational Medicine, Departament of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Article Synopsis
- This study focuses on the presence of human polyomaviruses (HPyV) in head and neck squamous cell carcinoma (SCC) samples, particularly examining the role of these viruses alongside traditional risk factors like smoking and alcohol.
- Researchers analyzed 60 samples from different mouth and throat areas for four types of HPyV, finding a 60% positivity rate for JCPyV and low rates for MCPyV (5%) with no instances of BKPyV or TSPyV.
- The study concluded that while JCPyV is commonly present in oral cavity and oropharyngeal SCC, no strong links to patient demographics or clinical characteristics were found, except for a notable association between JCP
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!