Palladium(ii)-catalyzed synthesis of dibenzothiophene derivatives the cleavage of carbon-sulfur and carbon-hydrogen bonds.

A new process has been developed for the palladium(ii)-catalyzed synthesis of dibenzothiophene derivatives the cleavage of C-H and C-S bonds. In contrast to the existing methods for the synthesis of this scaffold by C-H functionalization, this new catalytic C-H/C-S coupling method does not require the presence of an external stoichiometric oxidant or reactive functionalities such as C-X or S-H, allowing its application to the synthesis of elaborate π-systems. Notably, the product-forming step of this reaction lies in an oxidative addition step rather than a reductive elimination step, making this reaction mechanistically uncommon.