Estimation of Pentraxin 3 and Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study.

Introduction: Periodontal diseases are inflammatory in nature involving interplay between the bacterial plaque and the micro-organisms, with the response of the host playing a pivotal role in either attenuating or eliminating the disease. Rheumatoid Arthritis (RA) is also a chronic inflammatory disease which shares common risk factors with periodontitis. and Pentraxin 3 (an acute inflammatory protein) have been observed to be associated with both the diseases.

Aim: This study was done to determine if there was any association between and Pentraxin 3 levels in patients with RA and Chronic Periodontitis in comparison with Healthy controls.

Materials And Methods: This observational study was conducted on 90 subjects (42 Males and 48 Females) aged between 30-60 years. The subjects were selected from the out patient ward of a tertiary referral care hospital. The selected subjects were equally divided into three groups. Group I: Comprising of 30 patients with RA and chronic periodontitis who were in turn, subdivided into Group I- A (n=15) -Patients just diagnosed with RA and Group I- B (n=15) Patients under medications for more than three months. Group II: Patients with Chronic Periodontitis (n=30) and Group III: Healthy Controls (n=30) Intergroup comparison for continuous data was done by One-way analysis of variance test followed by Bonferroni's post-hoc test. Intragroup comparison for continuous data was done by paired t-test.

Results: Intergroup comparison between Group I and Group II did not show any statistical difference pertaining to the clinical parameters except for the Gingival Index (GI) which was found to be higher in Group II (Mean= 2.07) when compared to Group I (Mean=1.59). Intragroup comparison between Group IA and Group IB was statistically significant for GI, Plaque Index (PI), and Clinical Attachment Levels (CAL). Intragroup comparison between Group I-A and Group I-B showed that both and Pentraxin 3 Levels were higher in Group I- A.

Conclusion: In this study, it was observed that there was a positive association between and Pentraxin 3 levels in patients with rheumatoid arthritis and periodontitis.