An investigation is presented of the tensions that emerged during the Spanish flu epidemic in the city of Sorocaba, Brazil, between October and December 1918. It draws on previously unused primary sources, namely the narratives contained in the local press, taking the Santa Rosália factory as a case study, particularly its owner's refusal to maintain the work stoppage at the height of the epidemic, even when requested to by the municipal authority. This research contributes to the study of epidemics in Brazil's inland municipalities, emphasizing how local history can contribute to investigations of the history of disease in the country.
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http://dx.doi.org/10.1590/S0104-59702017000200007 | DOI Listing |
JAMA Neurol
January 2025
Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.
Importance: There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) and on RNA interference (RNAi) therapeutics in general. This study presents the longest-term data to date on patisiran for hATTR-PN.
Objective: To present the long-term efficacy and safety of patisiran in adults with hATTR-PN.
JAMA Neurol
January 2025
Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Importance: Although 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established cross-sectional biomarker of brain metabolism in dementia with Lewy bodies (DLB), the longitudinal change in FDG-PET has not been characterized.
Objective: To investigate longitudinal FDG-PET in prodromal DLB and DLB, including a subsample with autopsy data, and report estimated sample sizes for a hypothetical clinical trial in DLB.
Design, Setting, And Participants: Longitudinal case-control study with mean (SD) follow-up of 3.
Anesth Analg
February 2025
From the Department of Surgical Specialties and Anesthesiology of São Paulo State University (UNESP), Medical School, Botucatu, Brazil.
Background: Proficiency in endotracheal intubation (ETI) is essential for medical professionals and its training should start at medical schools; however, large caseload may be required before achieving an acceptable success rate with direct laryngoscopy. Video laryngoscopy has proven to be an easier alternative for intubation with a faster learning curve, but its availability in medical training may be an issue due to its high market prices. We devised a low-cost 3-dimensionally printed video laryngoscope (3DVL) and performed a randomized trial to evaluate if the intubation success rate on the first attempt with this device is noninferior to a standard commercially available video laryngoscope (STVL).
View Article and Find Full Text PDFEcotoxicology
January 2025
Unidad Académica Mazatlán, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Mazatlán, Sinaloa, México.
Monitoring the dynamics of contaminants in ecosystems helps understand their potential effects. Seabirds have been used as biomonitors of marine ecosystems for this purpose. However, exposure and vulnerability to pollutants are understudied in tropical species, and the relationships between various pollutants and the trophic ecology of seabirds are poorly understood.
View Article and Find Full Text PDFClin Transl Oncol
January 2025
Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
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