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Acceptability and feasibility of a urine-based tenofovir adherence assay for monitoring and providing feedback on PrEP adherence in Kenya.
AIDS Care
December 2024
School of Public Health, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Objective measures of oral PrEP adherence - especially point-of-care (POC) measures that enable real-time assessment, intervention, and feedback - have the potential to improve adherence. Our team previously developed and validated a novel urine-based POC metric of PrEP adherence. In this study, we sought to determine whether this assay is acceptable and feasible among women taking PrEP and PrEP providers in Kenya.
View Article and Find Full Text PDFHigh recent PrEP adherence with point-of-care urine tenofovir testing and adherence counselling among young African women: results from the INSIGHT cohort.
J Int AIDS Soc
December 2024
Department of Global Health, University of Washington, Seattle, Washington, USA.
Introduction: Adolescent girls and young women (AGYW) account for two-thirds of new HIV infections in Africa. African AGYW have had high uptake of oral HIV pre-exposure prophylaxis (PrEP) but low adherence, which might be improved by point-of-care adherence monitoring with tailored counselling.
Methods: From August 2022 to July 2023, we conducted a PrEP demonstration project with sexually active AGYW ages 16-30 years from 20 sites in South Africa, Eswatini, Kenya, Malawi, Uganda and Zambia.
The High Burden of Asymptomatic Kidney Diseases in Individuals with HIV: A Prospective Study from a Tertiary Care Center in India.
Indian J Nephrol
July 2024
Department of Pathology, Apollo Hospitals, Hyderabad, Telangana, India.
Background: HIV infection is associated with a significant kidney disease burden. This study is aimed to screen for kidney disease in all HIV patients on highly active anti retroviral therapy (HAART), study clinico-histological correlation, and assess the impact of early diagnosis on the clinical course.
Materials And Methods: It was a prospective, longitudinal study done in a tertiary care hospital.
The Impact of Adherence Counselling Incorporating a Point of Care Urine Tenofovir Assay on Virologic Suppression among Individuals Failing Tenofovir-Lamivudine-Dolutegravir: A Pre - Post intervention Study.
Int J Infect Dis
December 2024
Centers for Disease Control and Prevention, Division of Global HIV and Tuberculosis, Atlanta, USA.
Objectives: To examine if point-of-care urine tenofovir testing-informed counseling could be used to improve virologic suppression (VS) among participants with virologic failure (VF) after ≥1 prior round of enhanced adherence counseling (EAC).
Methods: Participants were enrolled from 42 clinics across Namibia. At each monthly medication pick-up, participants completed the point-of-care urine test and received EAC informed by this testing (EAC+).
Proteinuria and albuminuria among a global primary cardiovascular disease prevention cohort of people with HIV.
AIDS
January 2025
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Objectives: To determine baseline prevalence of proteinuria and albuminuria among participants from the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) and evaluate associated risk factors.
Design: Cross sectional analysis of a baseline sample of participants from the REPRIEVE Trial.
Methods: REPRIEVE is an international primary cardiovascular prevention randomized controlled trial (RCT) of pitavastatin calcium vs.
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