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http://dx.doi.org/10.1080/00015385.2017.1320021DOI Listing

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Article Synopsis
  • - Brugada phenocopy (BrP) is characterized by a Brugada-like ECG pattern and can occur due to various conditions, but it doesn't increase the risk of serious heart issues like Brugada syndrome (BrS) does.
  • - A case is presented of a 69-year-old woman with moderate hyponatremia who exhibited a saddle-back ST-segment elevation on her ECG, which was linked to her liver metastases compressing her heart.
  • - The ECG changes resolved quickly after treating her hyponatremia with sodium chloride, demonstrating that even mild electrolyte imbalances can lead to BrP when compounded by other factors like mechanical heart compression.
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Pilsicainide is a class Ic antiarrhythmic agent that exhibits fully selective sodium channel blockade. In Japan, it is one of the most prescribed medicines for rhythm control in atrial fibrillation. Pilsicainide is mainly excreted by the kidney.

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A 79-year-old man presented with impaired consciousness, fever with a body temperature of 41.1°C, and an electrocardiogram showing significant ST segment elevation in leads V1-6, coved-type ST elevation in leads V1-3, and partial right bundle branch block. Echocardiography revealed notable left ventricle dysfunction with apex-based akinesis.

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Brugada syndrome (BrS) is an inherited channelopathy characterized on ECG by coved (type 1) or saddle-back (type 2) ST-segment elevation (STE) of 2 or more mm in the right precordial leads and is associated with an increased risk of malignant ventricular arrhythmias. The term Brugada phenocopy (BrPh) indicates conditions that may reversibly induce Brugada-like ECG pattern in patients without true BrS; e.g.

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