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Improving the benefits of HIV testing and referrals in large household surveys through active linkages to care: lessons and recommendations from the Namibia population-based HIV impact assessment (NAMPHIA), 2017.
AIDS Care
October 2021
Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.
In household-based surveys that include rapid HIV testing services (HTS), passive referral systems that give HIV-positive participants information about how and where to access ART but minimal follow-up support from survey staff may result in suboptimal linkage. In the 2017 Namibia Population-based HIV Impact Assessment (NAMPHIA), we piloted a system of active linkage to care and ART (ALCART) that utilized the infrastructure of existing community-based partner organizations (CBPOs). All HIV-positive participants age 15-64 years not on ART were given standard passive referrals to ART plus the option to participate in ALCART.
View Article and Find Full Text PDFMutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype.
Cancer Cell
February 2019
Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands. Electronic address:
Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations from 17 families, of which 26 developed one (n = 10) or multiple (n = 16) malignancies in 14 different tissues. An unexpected high breast cancer incidence was observed in female carriers (60%).
View Article and Find Full Text PDFNutritional supplements: simply a waste of money or poorly targeted?
Clin Exp Optom
July 2014
Sandringham, Victoria, Australia.
Alstrom syndrome in four sibs from northern Jordan.
Ann Saudi Med
May 2007
National Center for Diabetes, Endocrinology, and Genetics, Amman, Jordan.
How to make clinical decisions from statistics.
Clin Exp Optom
May 2006
Sandringham, Victoria, Australia.
Best practice health care depends on clinicians understanding and applying the results of trials in clinical practice. These results are most often presented in the language of statistics, which can be bewildering and even misleading for those of us who have only a limited understanding of the terms used in reporting statistics. This communication provides a simple explanation of some of the more common types of trials and their descriptors, presented in a way that should allow clinicians to understand, assess and apply the results.
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